Tag Archives: Depression

Men and Depression

As a man who has suffered from depression and continues to attend a men’s depression and anxiety support group, I believe depression in men is greatly under-reported.  Many men do not admit to having depression.  Some feel they just need to “Buck up” or “Pull their bootstraps up”, so they do not consider getting support. … Read More »

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »